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Systems genetics of green microalgae –
from fundamental cell biology to translational applications.

| Research projects

A hub of photosynthetic production and a central metabolic factory, the chloroplast is the plant’s major energy producer, converting sunlight and carbon dioxide (CO2) into chemical energy, oxygen (O2) and building blocks for plant growth—both in the sea and on land. As such, it is at the heart of all the food webs on earth and is inextricably tied to our climate, as well as to our atmosphere’s CO2 and O2 levels. 


High photosynthesis efficiency and plant resilience to fluctuating environments are vital to ensure sufficient food and feedstocks for the world’s growing population.

Thus, uncovering the mechanisms of biogenesis and degradation of the chloroplast is necessary to pave the way for the synthetic engineering of crops that can better withstand the projected environmental changes due to global warming.

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Systematic mapping of the chloroplast protein import system

The vast majority of proteins (~3000) that ensure the proper functioning of the chloroplast are encoded by nuclear genes and must therefore be imported from the cytosol, with only ~100 proteins encoded in the chloroplast genome itself...
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Elucidating the genetic network that drives retrograde signaling during chloroplast proteotoxic stress

Exposure to various environmental conditions such as high light may lead to the accumulation of misfolded proteins in the chloroplast that may result in proteotoxic stress. The chloroplast Unfolded Protein Response (cpUPR) during which...
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Elucidating guiding principles of the Chlamydomonas-plant microbiota ecosystem

Plants develop and grow within a complex biochemical ecosystem. The chemical composition of the rhizosphere has a major effect on root health and growth. Importantly, primary metabolites dictate the ...
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| Lab resources

 JoVE Journal 

High-Throughput Robotically Assisted Isolation of Temperature-sensitive Lethal Mutants in Chlamydomonas reinhardtii.

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The Chlamydomonas Resource Center maintains algal strains, plasmids and protocols for the entire community. Among which you can find our temp-sensitive lethal mutant collection.


 The Chlamydomonas Sourcebook 

Book • Second Edition • 2009

Edited by:
Elizabeth H. Harris, David B. Stern and George B. Witman


 The Chlamydomonas insertional mutant collection 

CLiP: Chlamydomonas Library Project 

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